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182,183 Moreover, reduced developmental synaptic pruning in layer V pyramidal neurons in the postmortem ASD temporal lobe has been shown to hyperactive mTOR and defective autophagy

4 The proposed mechanism involves both direct neuroprotective effects (via eNOS-NO pathway preservation of vascular supply to injured nerve) and indirect effects via modulation of the inflammatory microenvironment at the injury site

As a synthetic analog, DSIP exhibits poor oral bioavailability and is typically administered via parenteral routes for research purposes

Oral peptides offer greater convenience and ease

Vitamin B12 is available OTC as a dietary supplement